At a glance
Effects
- Accelerated wound & tissue repair: Stimulates fibroblast migration, collagen deposition, and re-epithelialization, supporting faster closure of wounds and soft-tissue injuries [1].
- Tendon & ligament recovery: Promotes skeletal muscle and tendon recovery in preclinical models; used off-label for tendinopathies and partial tears [6].
- Anti-inflammatory signalling: Reduces pathological inflammation while preserving normal immune clearance, creating a cleaner environment for repair [1].
- Angiogenesis (new blood vessel growth): Promotes endothelial cell migration and capillary formation, improving nutrient delivery to healing tissue [6].
- Cardioprotection: Reduces infarct size and preserves contractile function after myocardial ischaemia via anti-apoptotic and progenitor-cell mechanisms [5].
- Neuroprotective potential: Promotes survival and differentiation of oligodendrocyte precursor cells; under investigation for demyelinating conditions [3].
Peptide (43-amino-acid actin-binding)
~30 min plasma; tissue effects outlast plasma clearance significantly
Subcutaneous or intramuscular injection; topical / ophthalmic in trials
Investigational / not FDA-approved; WADA-banned in sport
Preclinical + small Phase 1–2 trials (IV); no large human RCTs for SC use
About Thymosin beta-4
Every point here is drawn from public medical and harm-reduction sources. A bracketed number after a claim — like [1]— is a reference: tap it to open the exact source it's based on (numbered list at the bottom). It is not a rating or score. Educational information, not medical advice.
Product specifics
- Est. delivery
- 3–7 business days · EU tracked
Product details as stated by the vendor (claims, not independently verified). Delivery is our standard EU estimate.
What it is
Thymosin Beta-4 (Tβ4) is a naturally occurring 43-amino-acid peptide found in virtually all human tissues, best known for its roles in wound healing, tissue repair, and anti-inflammatory signalling [1]. Its synthetic analogue TB-500 is used in performance and recovery contexts for accelerated soft-tissue and tendon repair [2].
How it works
Tβ4 works primarily by binding to monomeric G-actin, maintaining a readily available pool of actin for rapid cytoskeletal reorganisation [3]. This controls cell migration, directing repair cells to injured sites more efficiently [1]. In parallel it modulates inflammatory cytokines — reducing excessive inflammation while preserving the immune clearance needed for clean tissue remodelling [1]. It also promotes angiogenesis (formation of new capillaries) [4], stimulates fibroblast migration and collagen deposition [1], and protects cells from oxidative stress and apoptosis during recovery [1]. In cardiac tissue it activates vascular and progenitor-cell growth following ischaemic injury [5].
Risks & side effects
Most important: The most important unresolved concern is that early preclinical studies linked Tβ4's pro-angiogenic and cell-motility activity to enhanced tumour-cell metastasis in cancer models [7]. Anyone with an active or recent cancer diagnosis should not use this compound until definitive human safety data is available [7]. Additionally, all commercially available TB-500 is an unregulated research chemical; purity, concentration, and sterility cannot be guaranteed and represent a serious contamination risk independent of the peptide itself [8].
Common
Serious
- Theoretical promotion of tumour-cell metastasis via pro-angiogenic / pro-migratory mechanisms — avoid in any active or prior cancer diagnosis [7]
- Hypersensitivity / anaphylactic reaction — risk increases with repeated peptide exposure; patients with known hypersensitivity must not use it [10]
- Mild blood-pressure decrease in sensitive users due to vasodilatory angiogenic effects [11]
- Unknown long-term safety — no large-scale, long-term human trials exist; subcutaneous off-label use lacks dedicated clinical safety data [6]
Safety & harm reduction
- Active, suspected, or recent cancer — pro-angiogenic and pro-migratory mechanisms may enhance tumour metastasis [7]
- Known hypersensitivity to Thymosin Beta-4 or any peptide excipient — anaphylaxis risk [10]
- Athletes subject to WADA anti-doping code — Tβ4 and all derivatives are explicitly banned [12]
- Pregnancy or breastfeeding — no human safety data exist
- Anticoagulants / blood thinners — angiogenic promotion may theoretically interact with clotting dynamics; caution warranted
- Immunosuppressants — Tβ4 modulates immune signalling; combined effects unpredictable
- Other pro-angiogenic compounds (e.g. VEGF-pathway agents) — additive angiogenesis not characterised in humans
- Use only pharmaceutical-grade material prescribed by a licensed provider; unregulated 'research chemical' TB-500 carries serious contamination risk [8]
- Rotate injection sites to minimise localised tissue reaction [13]
- Reconstitute with bacteriostatic water under sterile conditions; discard any vial showing particulates or discolouration
- Not a substitute for established clinical wound, tendon, or cardiac care pathways [7]
Dosage context
No standardised therapeutic dosage for subcutaneous use has been established in human trials [6]. Phase 1 IV studies used escalating doses of 42–1260 mg with no serious adverse events, but these IV data do not translate directly to SC self-administration [14]. Commonly reported off-label practice involves subcutaneous injections, with some sources citing 0.25 mL daily for acute protocols and 2–3 injections per week for longer recovery courses [13] — these are community-reported, not clinically validated, and must not be treated as a prescription. Physician supervision is strongly advised before any use [2].
Sources
- 1.Age Well ATL — Thymosin Beta-4: Injury Recovery & Tissue Regeneration
- 2.Age Rejuvenation — Peptide Therapy: What is Thymosin Beta 4?
- 3.Peptide Society — Thymosin Beta-4: Regenerative Peptide (link unavailable)
- 4.ScienceDirect Topics — Thymosin Beta-4 Overview
- 5.Frontiers in Endocrinology — Progress on the Function and Application of Thymosin β4
- 6.BSCG — TB-500: Status, Risks, and Bans in Sport and Military
- 7.Peptide Dosing Protocols — TB-500 Dosing Guide 2026
- 8.Moonshot MP — TB-500 (Thymosin Beta-4): Benefits, Dosing & Side Effects
- 9.Swolverine — TB-500 Side Effects & Safety
- 10.Dr Oracle AI — Adverse Effects of TB-500 (Thymosin Beta-4)
- 11.Pulse & Remedy — TB-500: How Thymosin Beta-4 Supports Cellular Repair
- 12.Peptides.org — TB-500: Reviews, Clinical Trials, and Safety
- 13.Dr Dan Wool — Is Thymosin Beta-4 / TB500 the Future of Tissue Healing?
- 14.ResearchGate — Randomized Placebo-Controlled Study of IV Thymosin β4 in Healthy Volunteers
- 15.Peptides Lab UK — Peptide Half-Life Explained (2026)
This information is provided for educational and harm-reduction purposes only. It is not medical advice. These substances can carry serious health risks; effects and safe use vary by individual. Consult a qualified healthcare professional before use. Legal status varies by country — it is your responsibility to know your local law. We do not encourage misuse.
Other options for Thymosin beta-4· 4 offers
Same compound from different labs/brands and pack sizes. Tap a row to switch brand — the price and buy button update instantly.
| Brand | Form | Strength | Pack | Price | Per mg |
|---|---|---|---|---|---|
DriadaSelected | vial | 2 mg | 1 vial | 39,90 € | — |
Generic | vial | 5 mg | 10 vial | 269,99 € | — |
Generic | vial | 5 mg | 50 vial | 700,00 € | — |
Generic | vial | 5 mg | 50 vial | 700,00 € | — |
Substance reviews(4)
Independent reviews of this compound from the wider market — about the substance, not our delivery. Showing the 2 with written feedback.
- ★★★★★7 months ago
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- ★★★★★7 months ago
Perfect delivery delay, perfect package and perfect product!