At a glance
Effects
- Lean Muscle Growth: Strongly activates androgen receptors in skeletal muscle, producing significant lean mass gains — considered one of the most anabolic SARMs in preclinical and user-reported data [1][7].
- Strength & Power: Strongly activates androgen receptors in muscle tissue, improving neuromuscular efficiency and translating to heavier lifts and enhanced training performance [7].
- Fat Loss / Recomposition: Increases the body's ability to oxidise fat; users seeking recomposition frequently report it outperforms other SARMs in this context [5][8].
- Endurance & Recovery: May enhance endurance, stamina, and recovery speed during high-intensity workouts in anecdotal reports [5].
- Neuroprotective Potential: Preclinical evidence suggests neuroprotective activity via androgen-receptor activation in neural tissue, though this has not been confirmed in clinical trials [6].
SARM (non-steroidal)
~16–20 h (user est.); pharmacokinetic data suggest ~60 h [6][14]
Oral (liquid or capsule) [2]
Not FDA-approved; WADA-banned in all sports [3][6]
Not publicly established; WADA-listed — assume detectable in anti-doping tests [6]
About Testolone
Every point here is drawn from public medical and harm-reduction sources. A bracketed number after a claim — like [1]— is a reference: tap it to open the exact source it's based on (numbered list at the bottom). It is not a rating or score. Educational information, not medical advice.
Product specifics
- Est. delivery
- 3–7 business days · EU tracked
Product details as stated by the vendor (claims, not independently verified). Delivery is our standard EU estimate.
What it is
Testolone (RAD-140) is a non-steroidal selective androgen receptor modulator (SARM) originally developed by Radius Health as a potential treatment for muscle wasting, osteoporosis, and hormone-sensitive breast cancer [1][2]. It is used in performance and bodybuilding contexts for its potent anabolic effects and is classified as a research chemical — not approved by the FDA for human use [3].
How it works
RAD-140 selectively binds to androgen receptors in skeletal muscle and bone tissue, activating anabolic signalling pathways that drive muscle growth and increased strength [1][4]. Unlike traditional anabolic steroids, it does not interact with the aromatase enzyme and therefore does not convert to estrogen [5]. Its tissue-selective mechanism also means it has minimal activity at reproductive tissues such as the prostate, theoretically reducing classic androgenic side effects [4][5]. It also exhibits early-stage neuroprotective properties in preclinical research by activating the MAPK/ERK signalling pathway in neural tissue [6].
Risks & side effects
Most important: RAD-140 causes significant suppression of natural testosterone production — users report total testosterone falling to below 200 ng/dL after 6–8 weeks at 20 mg/day — and documented clinical case reports have linked it to serious hepatotoxicity (drug-induced liver injury, including jaundice and acute liver failure) and acute myocarditis [1][9][10]. These are not theoretical risks: they have been recorded in published medical case reports.
Common
- Testosterone suppression — significant and dose-dependent; expect LH/FSH and total testosterone reduction [1][9]
- Lipid dysregulation — decreased HDL, increased LDL, elevating long-term cardiovascular risk [10]
- Headaches and nausea [3]
- Fatigue and reduced libido during and post-cycle [9]
- Hair thinning / accelerated hair loss in predisposed individuals [3]
Serious
- Drug-induced liver injury (DILI) — elevated ALT/AST, jaundice, abdominal pain; some cases persisted post-discontinuation [9][10]
- Acute myocarditis — a published case report documents heart inflammation following RAD-140 use [11]
- Arterial thrombosis — RAD-140 can increase platelet activity; a case of arterial thrombosis has been documented in a user also on TRT [12]
- Severe endocrine disruption and prolonged hormonal dysregulation [1][3]
Safety & harm reduction
- Existing or history of liver disease or elevated liver enzymes [9][10]
- Cardiovascular disease, prior myocarditis, or clotting disorders — published case reports link RAD-140 to myocarditis and arterial thrombosis [11][12]
- Concurrent testosterone replacement therapy (TRT) without medical supervision — combination may significantly increase thrombosis risk [12]
- Competitive athletes subject to WADA or sports-body anti-doping rules — RAD-140 is prohibited [6]
- Pregnancy, breastfeeding, or those planning conception — androgenic activity poses fetal/hormonal risk [3]
- Adolescents and minors — growth plate and hormonal disruption risk; a myopericarditis case in a 16-year-old has been documented [13]
- Baseline bloodwork before starting: CBC, CMP, lipid panel, AST/ALT, total/free testosterone, LH, FSH [1][15]
- Mid-cycle bloodwork at weeks 4–6 to assess liver enzyme elevation and testosterone suppression [15]
- Post-cycle and post-PCT bloodwork to confirm hormonal recovery [15]
- Blood pressure monitoring throughout cycle given cardiovascular risk [10]
- Testosterone (TRT or AAS): concurrent use may substantially increase arterial thrombosis risk [12]
- Other SARMs (LGD-4033, YK-11, MK-677): stacking increases both anabolic effect and degree of suppression; stronger PCT required [14]
- Hepatotoxic agents (alcohol, paracetamol/acetaminophen at high doses, other oral AAS): additive liver stress risk [9][10]
- Anticoagulants: androgenic platelet-activating effects may interact unpredictably — clinical data lacking [12]
- Post-cycle therapy (PCT) is strongly recommended following any RAD-140 cycle due to significant testosterone suppression [1][9]
- Commonly reported PCT approach: Clomid or Nolvadex (tamoxifen) for 3–6 weeks starting approximately 12 days post-last dose (based on ~60 h half-life) — anecdotal, not clinical guidance [6][14]
- Liver support: TUDCA 500 mg/day and/or NAC throughout cycle to reduce hepatic stress — harm-reduction practice, not a proven preventive [8][15]
- Omega-3 supplementation during cycle to partially mitigate lipid dysregulation [15]
- Cycle length should not exceed 8–12 weeks; risk-to-reward ratio worsens beyond 12 weeks [14]
Dosage context
No clinically validated dosing protocol exists for RAD-140 in healthy humans. Anecdotally reported ranges among users are 10–20 mg/day orally, with 10–15 mg/day cited as covering the majority of use cases with fewer reported side effects [14][15]. All dosing information is anecdotal and not a clinical guideline. Significant testosterone suppression has been reported at 20 mg/day within 6–8 weeks [1].
Sources
- 1.Swolverine — RAD-140 Side Effects: Risks, Suppression, Liver Stress
- 2.LotiLabs — RAD-140 (Testolone) SARM: Research, Benefits & Risks
- 3.InsideBodybuilding — RAD-140 (Testolone): Results, Dosages
- 4.Swolverine — RAD-140 (Testolone) Guide: Benefits, Dosage, PCT
- 5.Predator Nutrition — RAD-140 Review: Benefits, Dosage & Side Effects
- 6.Muscle & Brawn — Testolone RAD-140 SARM: Benefits, Uses, Dosage
- 7.Swolverine — RAD-140 Dosage Guide: Safe Cycles, PCT and Recovery
- 8.MuscleChem — RAD-140 Side Effects: Complete Guide to Testolone Risks
- 9.PMC / NIH — SARM RAD-140 Leading to Liver Injury: A Case Report (2024)
- 10.Consensus.app — Testolone Adverse Effects Summary
- 11.PMC / NIH — Acute Myocarditis From SARM RAD-140 (Testolone) Use
- 12.Annals of Internal Medicine: Clinical Cases — Arterial Thrombosis in a Patient Receiving RAD-140 (2026)
- 13.FitScience — RAD-140 Testolone: Dosage, Half-life, PCT
- 14.DadBod2Fit — RAD-140 (Testolone) 2026: Dosage, Cycle Design, Safety (link unavailable)
- 15.Sports Technology Labs — Liquid Testolone RAD-140 Product Page
This information is provided for educational and harm-reduction purposes only. It is not medical advice. These substances can carry serious health risks; effects and safe use vary by individual. Consult a qualified healthcare professional before use. Legal status varies by country — it is your responsibility to know your local law. We do not encourage misuse.
Other options for Testolone· 4 offers
Same compound from different labs/brands and pack sizes. Tap a row to switch brand — the price and buy button update instantly.
This compound comes in different forms (e.g. injectable vs oral vs topical). Cost per mg is only comparable within the same form.
| Brand | Form | Strength | Pack | Price | Per mg |
|---|---|---|---|---|---|
Generic | blister-pack | 10 mg/tab | 50 tab | 94,90 € | €0.190/mg |
Intex Pharma | blister-pack | 10 mg/tab | 60 tab | 99,99 € | ★€0.167/mg |
Generic | — | — | 104,99 € | — | |
GenericSelected | oral-liquid | 20 mg/ml | 100 ml | 219,99 € | €0.110/mg |
Substance reviews(1)
Independent reviews of this compound from the wider market — about the substance, not our delivery.
- ★★★★★2 months ago
spoke to me like sht ..lied about about where it was being sent from .. leaked everywhere ,wasnt even labelled properly ,stay away from this scum bag