At a glance
Effects
- Lean muscle growth: Users commonly report rapid increases in lean body mass — anecdotally 8–12 lb in 3–4 weeks — driven by androgen-receptor-mediated protein synthesis and nitrogen retention [5][8].
- Strength gains: Widely considered one of the most potent oral steroids for acute strength increases; improvements are often apparent within the first week of use [4][8].
- Dry, hard physique: As a non-aromatising DHT derivative with no estrogenic activity, it produces no water retention or bloating, yielding a lean, hard appearance valued in both bulk and cut phases [7][9].
- Fat loss / body-recomposition: Some users incorporate it during a caloric deficit for recomposition; the dry gains and metabolic effects make it useful as a cutting compound [9].
- Testosterone suppression (negative effect): Methyldrostanolone significantly suppresses the hypothalamic-pituitary-gonadal (HPG) axis, reducing endogenous testosterone production — sometimes within 1–2 weeks of use [6][10].
- Hepatic stress (negative effect): Elevated liver enzymes, cholestatic jaundice, and bile-flow impairment are well-documented adverse effects of the 17α-alkylated structure [11][12].
Anabolic-androgenic steroid (AAS), DHT derivative, 17α-alkylated oral
8–12 hours (split dosing recommended) [1][8]
Oral (tablet/capsule)
17α-alkylated — high liver burden [3][11]
None — DHT-based, no estrogenic conversion [7]
About Methyldrostanolone
Every point here is drawn from public medical and harm-reduction sources. A bracketed number after a claim — like [1]— is a reference: tap it to open the exact source it's based on (numbered list at the bottom). It is not a rating or score. Educational information, not medical advice.
Product specifics
- Est. delivery
- 3–7 business days · EU tracked
Product details as stated by the vendor (claims, not independently verified). Delivery is our standard EU estimate.
What it is
How it works
Methyldrostanolone works by binding with high affinity to androgen receptors in skeletal muscle, promoting protein synthesis, nitrogen retention, and muscle hypertrophy [5][1]. Its 2α-methyl group heightens resistance to breakdown by the 3-hydroxysteroid dehydrogenase enzyme in muscle tissue, amplifying its anabolic potency [2]. Its 17α-methylation allows oral bioavailability but simultaneously burdens the liver, as the compound resists first-pass hepatic metabolism [3][6]. Unlike many AAS, it does not aromatise to estrogen — being a DHT derivative — so estrogenic side effects such as water retention are minimal [7].
Risks & side effects
Most important: Methyldrostanolone carries a severe and well-documented risk of drug-induced liver injury (DILI), including cholestasis (impaired bile flow), hepatitis, and acute liver failure — it was the most common AAS implicated in a systematic review of 52 DILI cases [11]. Signs of serious liver damage (dark urine, jaundice, right-upper-quadrant pain) require immediate cessation and urgent medical evaluation [8].
Common
- Elevated liver enzymes (ALT/AST) [11]
- HDL (good cholesterol) reduction and LDL (bad cholesterol) increase [10][13]
- Increased blood pressure [8][13]
- Testosterone suppression / low-T symptoms (fatigue, low libido) [6][10]
- Acne and oily skin [6][7]
- Lethargy and appetite suppression, especially weeks 2–3 [8]
- Joint pain / 'dry joints' (lack of estrogenic water retention) [14]
- Mood swings, irritability [7]
Serious
- Cholestatic hepatitis (bile-flow obstruction) with jaundice and pruritus [11][12]
- Acute kidney injury / renal failure (co-reported with liver DILI cases) [11][3]
- Severe HDL crash raising cardiovascular risk [8][13]
- Significant hypertension requiring medical management [8]
- Hypogonadism if PCT is omitted post-cycle [6][10]
- Testicular atrophy [14]
Rare
- Acute liver failure requiring hospitalisation [11]
- Peliosis hepatis (blood-filled hepatic cysts) — class-level risk for 17α-alkylated steroids [15]
- Left ventricular strain / cardiac remodelling from sustained hypertension [8]
- Male-pattern hair loss acceleration [7][14]
- Infertility (prolonged suppression) [6]
Safety & harm reduction
- Pre-existing liver disease or elevated baseline liver enzymes [11]
- Pre-existing cardiovascular disease, hypertension, or dyslipidaemia [8][13]
- Renal (kidney) impairment [11]
- Women (high androgenic potency; virilisation risk) [1]
- Under 25 years of age (HPG axis and skeletal development still maturing) [9]
- Concurrent use of other hepatotoxic drugs, alcohol, or recreational substances [9][11]
- Anyone not willing or able to obtain pre- and post-cycle bloodwork [8]
- Liver function tests (ALT, AST, ALP, bilirubin) — baseline, mid-cycle, and post-cycle [11][8]
- Lipid panel (HDL, LDL, total cholesterol, triglycerides) — baseline and during cycle [13][8]
- Blood pressure — monitored throughout; stop if sustained elevation occurs [8]
- Full testosterone / hormonal panel (total T, LH, FSH) post-cycle to guide PCT [6][10]
- Renal function (creatinine, eGFR) — especially if any signs of kidney stress arise [11]
- Stop immediately if: dark urine, pale/clay-coloured stools, yellow skin or eyes (jaundice), or right-upper-quadrant abdominal pain [8][11]
- Other 17α-alkylated oral steroids (e.g. oxandrolone, stanozolol) — additive hepatotoxicity; do NOT combine [11]
- Alcohol — synergistic liver stress; avoid entirely during cycle [9]
- NSAIDs (ibuprofen, naproxen) — added hepatic and renal burden [15]
- Anticoagulants (e.g. warfarin) — AAS may potentiate anticoagulant effect [15]
- Antihypertensives — blood-pressure effects may require dose adjustment [8]
- Other nephrotoxic substances — additive kidney injury risk [11]
- Liver support: TUDCA (tauroursodeoxycholic acid) and/or NAC (N-acetyl cysteine) throughout cycle and several weeks post-cycle [9]
- Cycle length: Strictly limit to 4 weeks maximum due to hepatotoxicity; many harm-reduction sources recommend 2–3 weeks [9][12]
- Dosage: Commonly reported range is 10–30 mg/day; 10–15 mg/day is advised as a starting point. Split into two daily doses to match 8–12 hour half-life [1][8]
- Post-cycle therapy (PCT): SERM (e.g. tamoxifen/Nolvadex or clomiphene) is mandatory; begin 3–5 days after last dose and run for 4 weeks minimum [6][10]
- Exogenous testosterone base: Strongly advised alongside any Superdrol cycle to prevent low-testosterone symptoms [13]
- Avoid stacking with other oral (17α-alkylated) steroids — hepatotoxicity is dose- and duration-additive [11]
- Avoid alcohol, recreational drugs, and other hepatotoxins for the duration of the cycle and PCT [9]
Dosage context
There is no medically approved or prescribed dosage — methyldrostanolone was never a pharmaceutical product [4]. Commonly reported non-medical usage ranges from 10–30 mg/day orally, with 10–15 mg/day often cited as a cautious starting point; doses above 20 mg/day significantly increase hepatic strain [1][8]. Cycle duration is typically capped at 4 weeks due to hepatotoxicity risk [9]. These figures are community-reported only, not a prescription or clinical recommendation.
Sources
- 1.Anabolic Planner — Superdrol (Methasterone)
- 2.Pharmacom Labs — Methyldrostanolone product overview
- 3.Grokipedia — Superdrol
- 4.Anabolic Planner — M-Drol (Superdrol)
- 5.ScienceDirect — Polymorphism and β-cyclodextrin complexation of methyldrostanolone
- 6.Anabolic Planner — Superdrol (Methasterone) full profile
- 7.Wikipedia — Methasterone
- 8.Fit Science — Superdrol Guide: Dosage, Half-Life, Methasterone
- 9.Astera Shop — Methyldrostanolone (Superdrol) (link unavailable)
- 10.Anabolic Planner — M-Drol side-effect profile
- 11.PubMed / PMC — AAS drug-induced liver injury: 52-case review (RUCAM)
- 12.European Review — Hepatotoxicity associated with illicit AAS use in doping
- 13.Insyde Out Fitness — Superdrol (Methyldrostanolone)
- 14.Steropedia — Superdrol / Methasterone
- 15.Synapse / PatSnap — Side effects of 17α-alkylated steroids
This information is provided for educational and harm-reduction purposes only. It is not medical advice. These substances can carry serious health risks; effects and safe use vary by individual. Consult a qualified healthcare professional before use. Legal status varies by country — it is your responsibility to know your local law. We do not encourage misuse.