At a glance
Effects
- Rapid lean muscle growth: Reported anabolic-to-androgenic ratio of ~230:30 [4]; animal models showed ~23× the myotropic activity of testosterone propionate [9]. Users report significant mass gains within weeks [10].
- Strength increase: Enhances neuromuscular efficiency and protein synthesis; rapid strength increases are commonly reported, especially during short blast phases [10].
- Body recomposition: Unlike many bulking steroids, MENT is reported to simultaneously build muscle and promote fat loss, making it useful for recomposition phases [11].
- Libido maintenance: Despite being a 19-nor compound, MENT's lack of SHBG binding and high AR affinity can sustain sexual function — an unusual property for this drug class [3][12].
- Profound HPG suppression: Potently suppresses LH, FSH, and endogenous testosterone — the basis for its contraceptive research, but a major recovery concern post-cycle [7][8].
- Estrogenic conversion: Aromatises to 7α-methylestradiol, a potent oestrogen metabolite, which can cause gynecomastia and water retention if not managed with an aromatase inhibitor [13][14].
Anabolic-androgenic steroid (19-nortestosterone derivative)
~8–12 h (acetate ester, IM); unesterified MENT ~40 min IV
Intramuscular injection (also subcutaneous implant in research)
Prohibited — S1 Anabolic Agents
~230 : 30
About Trestolone Acetate
Every point here is drawn from public medical and harm-reduction sources. A bracketed number after a claim — like [1]— is a reference: tap it to open the exact source it's based on (numbered list at the bottom). It is not a rating or score. Educational information, not medical advice.
Product specifics
- Est. delivery
- 3–7 business days · EU tracked
Product details as stated by the vendor (claims, not independently verified). Delivery is our standard EU estimate.
What it is
Trestolone Acetate (MENT Acetate) is a synthetic anabolic-androgenic steroid (AAS) and progestogen derived from nandrolone (19-nortestosterone), distinguished by a 7α-methyl group that markedly boosts its potency [1][2]. Originally researched as a male hormonal contraceptive and androgen replacement agent, it has never been approved or marketed for clinical use [1][2].
How it works
MENT acts as a potent agonist at the androgen receptor (AR) — with binding affinity reported to be 2–3× that of testosterone — driving protein synthesis, nitrogen retention, and red blood cell production [3][4]. Its 7α-methyl group prevents 5α-reduction to DHT, so it remains active in muscle without converting to weaker or more androgenic metabolites [5][6]. It also binds the progesterone receptor, contributing to powerful suppression of the hypothalamic-pituitary-gonadal (HPG) axis: LH and FSH are strongly suppressed, shutting down endogenous testosterone and sperm production [7][8]. The acetate ester is a prodrug, rapidly hydrolysed by blood esterases to release free MENT [3].
Risks & side effects
Most important: Trestolone causes profound, rapid suppression of the hypothalamic-pituitary-gonadal axis, shutting down natural testosterone and sperm production at even low doses [7][8]; without careful post-cycle therapy, hormonal recovery can be prolonged and potentially incomplete [15]. Cardiovascular strain — including adverse lipid shifts (LDL↑/HDL↓) and elevated blood pressure — represents a serious concurrent risk [16][17].
Common
Serious
- Profound suppression of LH, FSH, and endogenous testosterone — requires PCT [7][8]
- Adverse lipid profile: LDL increase, HDL decrease — cardiovascular disease risk [16][17]
- Liver enzyme elevations (injectable route lower risk than oral 17-aa, but monitoring required) [19][20]
- Infertility / azoospermia with sustained use [7]
- Virilisation in women (facial hair, voice deepening, clitoral enlargement) [21]
- Decreased bone mineral density if oestrogen levels remain chronically low [6]
Safety & harm reduction
- Women who are pregnant or may become pregnant (androgenic/virilising teratogen) [21]
- Anyone with pre-existing liver disease or elevated liver enzymes [19][20]
- Anyone with a history of cardiovascular disease, hypertension, or dyslipidaemia [16][17]
- Men with prostate cancer or suspected prostate pathology [1]
- Minors / adolescents (risk of premature epiphyseal closure) [1]
- Full lipid panel (LDL, HDL, triglycerides) at baseline and every 4–6 weeks on-cycle [15][17]
- Liver function tests (ALT, AST, ALP) at baseline and regularly on-cycle [19][20]
- Blood pressure — monitor frequently; target <130/80 mmHg [17]
- Full blood count / haematocrit (polycythaemia risk) [16]
- Hormone panel: LH, FSH, total testosterone, oestradiol, prolactin [15]
- PSA in men over 40 [1]
- Anticoagulants (e.g. warfarin): AAS can potentiate anticoagulant effect — INR monitoring required [16]
- Aromatase inhibitors (anastrozole, letrozole, exemestane): co-administration strongly recommended to control 7α-methylestradiol levels [14][23]
- Insulin / oral hypoglycaemics: AAS may alter insulin sensitivity [16]
- Other hepatotoxic agents (including alcohol, paracetamol/acetaminophen at high doses): additive liver stress [19]
- Other AAS or hormonal agents: additive suppression and cardiovascular risk [15]
- Post-cycle therapy (PCT) with a SERM (e.g. tamoxifen or clomifene) is essential to restore LH/FSH and endogenous testosterone after any cycle [15]
- Aromatase inhibitor (AI) should be on hand before starting; begin at first signs of oestrogen-related effects [14][23]
- Liver support supplements (e.g. TUDCA, NAC, milk thistle) are commonly co-administered, though they do not eliminate hepatic risk [24]
- Due to the short half-life, daily or every-other-day injections are needed to maintain stable plasma levels [22][23]
- Limit cycle length to 4–6 weeks where possible to reduce cardiovascular and hormonal burden [10]
Dosage context
No approved medical dosage exists for performance use. Clinical contraceptive research implants delivered sub-1 mg/day of free MENT [22]. Community-reported injectable doses range broadly and far exceed clinically studied amounts — these are unvalidated, carry escalating risk, and are not a prescription or recommendation. Short cycles (4–6 weeks) are widely recommended within user communities to limit cumulative cardiovascular and hormonal risk [10][15]. Frequent dosing (every 1–2 days) is required due to the short acetate ester half-life [22][23].
Sources
- 1.Wikipedia — Trestolone
- 2.Wikipedia — Trestolone acetate
- 3.BenchChem — Trestolone Acetate (CAS 6157-87-5)
- 4.TrainNow — Trestolone Acetate Dosages and Cycles
- 5.DrugBank — Trestolone acetate DB13958
- 6.Wikipedia — Trestolone (5α-reductase / aromatase)
- 7.NCATS Inxight Drugs — Trestolone Acetate
- 8.PureFitLab — Trestolone Acetate Action Mechanism and Risks
- 9.Grokipedia — Trestolone
- 10.Steroidify Blog — Trestolone: Testosterone on Steroids
- 11.SARMS.io — Trestolone Acetate Benefits, Dosage and Side Effects
- 12.Tiger Fitness — Inside Look at MENT
- 13.Swolverine — Anadrol vs Trestolone (MENT)
- 14.Stratelabs — Ultimate Guide to Trestolone Acetate (link unavailable)
- 15.ExcelMale — How to: Trestolone Doses
- 16.PMC — Medicinal Use of Testosterone and Related Steroids Revisited
- 17.WADA — Investigations into Human Metabolism of Trestolone (MENT)
- 18.Steroiduck — MENT Trestolone Cycle and Dosage (link unavailable)
- 19.DrOracle.ai — Does Trestolone Cause Liver Enzyme Abnormalities
- 20.DrOracle.ai — Hepatotoxicity Monitoring
- 21.PureFitLab — Virilisation in Women
- 22.Steroiduck — MENT Pharmacokinetics and Dosing (link unavailable)
- 23.Stratelabs — Aromatase Inhibitor Use with MENT (link unavailable)
- 24.SARMS.io — Liver Support with Trestolone
This information is provided for educational and harm-reduction purposes only. It is not medical advice. These substances can carry serious health risks; effects and safe use vary by individual. Consult a qualified healthcare professional before use. Legal status varies by country — it is your responsibility to know your local law. We do not encourage misuse.
Other options for Trestolone Acetate· 4 offers
Same compound from different labs/brands and pack sizes. Tap a row to switch brand — the price and buy button update instantly.
This compound comes in different forms (e.g. injectable vs oral vs topical). Cost per mg is only comparable within the same form.
| Brand | Form | Strength | Pack | Price | Per mg |
|---|---|---|---|---|---|
Intex PharmaSelected | vial | 50 mg/ml | 10 ml | 93,90 € | €0.188/mg |
Generic | vial | 50 mg/ml | 10 ml | 94,90 € | €0.190/mg |
Generic | vial | 100 mg/ml | 10 ml | 114,99 € | ★€0.115/mg |
Generic | oral-liquid | 40 mg/ml | 30 ml | 124,99 € | €0.104/mg |