At a glance
Effects
- GH Pulse Stimulation: Triggers robust, pulsatile endogenous GH secretion within minutes of injection, closely mimicking the body's natural GH release pattern [2][5].
- Muscle Growth & Repair: Elevated GH and downstream IGF-1 accelerate protein synthesis, satellite cell activation, and muscle recovery post-training [4].
- Fat Loss / Body Recomposition: Increased GH promotes lipolysis; users at higher body-fat percentages typically see more pronounced fat-loss effects [7].
- Appetite Stimulation (GHRP-6): GHRP-6 potently activates hypothalamic hunger-signalling pathways, causing intense hunger shortly after injection — a dose-dependent effect that resolves when the peptide is discontinued [8].
- Cardioprotective / Anti-fibrotic Effects: GHRP-6 has demonstrated cardioprotective properties in experimental models, reducing cardiac cell death, LV failure, and fibrosis via CD36 receptor activation [1][3].
- Wound Healing: GHRP-6 attenuates inflammatory mediators and fibrotic cytokines, improving wound closure and reducing hypertrophic scarring in preclinical models [9].
GH Secretagogue Peptide (GHRP family)
~15–30 min (subcutaneous; GHRP-2/6)
Subcutaneous or intramuscular injection
Not FDA-approved; research compound
~15–30 min post-injection
About GHRP Peptide
Every point here is drawn from public medical and harm-reduction sources. A bracketed number after a claim — like [1]— is a reference: tap it to open the exact source it's based on (numbered list at the bottom). It is not a rating or score. Educational information, not medical advice.
Product specifics
- Est. delivery
- 3–7 business days · EU tracked
Product details as stated by the vendor (claims, not independently verified). Delivery is our standard EU estimate.
What it is
Growth Hormone Releasing Peptides (GHRPs) — including GHRP-2, GHRP-6, and Hexarelin — are a family of small synthetic peptides that act as GH secretagogues, stimulating the pituitary gland to release endogenous growth hormone [1][2]. They are used in research and performance contexts for muscle growth, recovery, fat loss, and their emerging cardioprotective and anti-fibrotic properties [3].
How it works
GHRPs bind to and activate the GH secretagogue receptor 1a (GHSR1a), a ghrelin receptor found on pituitary somatotrophs and in the hypothalamus, triggering pulsatile GH release [1][4]. Some members (notably GHRP-6 and Hexarelin) also bind the CD36 receptor, which mediates cardioprotective and anti-fibrotic effects independent of GH secretion [1][3]. The resulting GH pulse drives downstream IGF-1 production in the liver, which carries out the anabolic, tissue-repair, and fat-mobilising effects [5]. Because GHRPs act through a receptor distinct from endogenous GHRH, they can synergise with GHRH analogues (e.g. CJC-1295) for amplified GH release [6].
Risks & side effects
Most important: Because GHRPs raise circulating IGF-1, there is a theoretical risk of promoting the growth of pre-existing or dormant tumour cells — GH/IGF-1 elevation is contraindicated in active or suspected malignancy [10]. Long-term effects of sustained GH and IGF-1 elevation in humans are not fully established, and these compounds are not FDA-approved for any indication [6].
Common
Serious
- Reduced insulin sensitivity / impaired glucose metabolism with prolonged use [10][14]
- Receptor desensitisation (GHS-R1a) with continuous high-frequency dosing, blunting GH response [15]
- Gynecomastia or libido suppression from sustained prolactin elevation (particularly GHRP-6) [8]
- Carpal tunnel syndrome with prolonged IGF-1 elevation [15]
- Theoretical promotion of tumour growth via elevated GH/IGF-1 — absolute contraindication in cancer history [10]
Safety & harm reduction
- Active or suspected malignancy, or any personal/family cancer history involving GH/IGF-1-sensitive tumours [10]
- Pregnancy or breastfeeding — no human safety data exist [10]
- Active diabetes or significant glucose dysregulation — GH elevation impairs insulin sensitivity and can unpredictably affect glucose control [14]
- Known hypersensitivity to any GHRP compound or peptide excipients [13]
- IGF-1 blood levels — to gauge GH response and avoid supraphysiological elevation [7]
- Fasting glucose and HbA1c — GH can impair insulin sensitivity, especially with concurrent anabolic steroid use [7]
- Prolactin levels — elevated prolactin can cause gynecomastia or libido suppression, particularly with GHRP-6 [8]
- Cortisol — transient elevation reported; relevant for users with adrenal concerns [12]
- GHRH analogues (CJC-1295, Sermorelin) — synergistic amplification of GH pulse; use cautiously and monitor IGF-1 [7]
- Insulin / oral hypoglycaemics — GH raises blood glucose; concurrent use may require dose adjustment and careful monitoring [14]
- Anabolic steroids — combination may compound glucose metabolism effects; additional monitoring warranted [7]
- Glucocorticoids (e.g. prednisone) — may blunt the GH-releasing response [6]
- No formal human drug-interaction studies have been conducted [10]
- Inject in a fasted state, or at minimum 2 hours after eating, to maximise GH pulse amplitude — elevated blood glucose significantly attenuates response [15]
- Cycle usage (e.g. 8–12 weeks on, 4 weeks off) to limit receptor desensitisation and mitigate long-term IGF-1 exposure risks [15]
- Dosing frequency should not exceed 2–3 times daily; diminishing returns occur above 300 mcg per dose [15]
- When stacking with GHRH analogues, start at the lower end of the dose range and titrate up based on IGF-1 monitoring [7]
- Ensure compound purity from a verified source — unregulated peptide products carry risks from contamination or inaccurate dosing [6]
Dosage context
Commonly reported research/community doses for GHRP-2 and GHRP-6 are 100–300 mcg per injection, administered subcutaneously 2–3 times daily [15]. Doses above 300 mcg per injection show diminishing returns for GH release [15]. These are community-reported ranges — not prescribed doses — and must not be treated as medical guidance. Individual response varies by age, body composition, and concurrent compounds [12].
Sources
- 1.Frontiers in Pharmacology – GHRP-6 Cardioprotection (2024)
- 2.PubMed – GHRP Clinical and Basic Aspects
- 3.OA Text – GHRP-6 Medical Potentialities Review
- 4.PMC – GHRP-2 Increases Food Intake in Healthy Men
- 5.PubMed – Growth Hormone-Releasing Peptide (GHRP) New Chemical Class
- 6.PubMed – Actions of GHRP Hexapeptide
- 7.Immortal Medicals – CJC-1295 & GHRP-6 Stack Guide
- 8.Swolverine – GHRP-6 vs GHRP-2 Side Effects
- 9.PMC – GHRP-6 Wound Healing
- 10.Peptide Treatments – GHRP-2 Safety & Contraindications
- 11.Loti Labs – GHRP-6 vs GHRP-2 Comparison
- 12.Liquivida – Role of GHRP-2 & GHRP-6 in Health
- 13.PEP DOSE – GHRP-6 Side Effects & Safety
- 14.Peptide Deck – IGF-1 LR3 Cancer Risk Context
- 15.Peptides Institute – GHRP-2 Research Profile
This information is provided for educational and harm-reduction purposes only. It is not medical advice. These substances can carry serious health risks; effects and safe use vary by individual. Consult a qualified healthcare professional before use. Legal status varies by country — it is your responsibility to know your local law. We do not encourage misuse.
Other options for GHRP Peptide· 4 offers
Same compound from different labs/brands and pack sizes. Tap a row to switch brand — the price and buy button update instantly.
This compound comes in different forms (e.g. injectable vs oral vs topical). Cost per mg is only comparable within the same form.
| Brand | Form | Strength | Pack | Price | Per mg |
|---|---|---|---|---|---|
Generic | — | — | 89,90 € | — | |
Generic | vial | 15 mg | 10 vial | 189,99 € | — |
GenericSelected | vial | 5 mg | 10 vial | 279,99 € | — |
Generic | — | — | 5mg/vial 10vials | 429,99 € | — |