At a glance
Effects
- Estrogen replacement: Replaces estrogen normally made by the body, relieving menopausal hot flushes and symptoms of low estrogen.[7]
- Feminizing effects: Used as high-dose estrogen in feminizing hormone therapy for transgender women.[3]
- Gonadotropin suppression: Lowers LH and FSH via negative feedback; this underlies its use in prostate cancer and contraception.[5][3]
- Symptom onset (hot flushes): When used for hot flushes, improvement is typically reported within 1 to 5 days of an injection.[7]
Estrogen (estradiol prodrug / ester)
Intramuscular injection or oral tablet[3]
IM in oil ~3.5 days (range 1.2–7.2); oral estradiol terminal ~14–17 h[6][16]
Once every 1–4 weeks[3][7]
Boxed warning: clots, stroke, cancer
About Estradiol Valerate
Every point here is drawn from public medical and harm-reduction sources. A bracketed number after a claim — like [1]— is a reference: tap it to open the exact source it's based on (numbered list at the bottom). It is not a rating or score. Educational information, not medical advice.
Product specifics
- Est. delivery
- 3–7 business days · EU tracked
Product details as stated by the vendor (claims, not independently verified). Delivery is our standard EU estimate.
What it is
How it works
After injection or oral dosing, esterases hydrolyse estradiol valerate into estradiol and valeric acid; the released estradiol binds estrogen receptors throughout the body to produce estrogenic effects.[4][1] Circulating estrogen also acts on the pituitary through negative feedback, lowering luteinising hormone (LH) and follicle-stimulating hormone (FSH).[5] When injected in oil it forms a depot in muscle and fat, so a single dose is absorbed slowly over several weeks.[3][6]
Risks & side effects
Most important: Estrogen therapy carries a boxed warning: it increases the risk of blood clots (deep vein thrombosis, pulmonary embolism), stroke, heart attack, and cancers of the breast, uterus and ovaries, and must not be used to prevent cardiovascular disease.[8][9][10] Stop the drug and seek emergency help for signs of a clot such as leg swelling, chest pain, sudden breathlessness, or sudden vision loss.[11]
Common
Serious
Safety & harm reduction
- People who currently have or have had breast cancer or other estrogen-dependent cancer[17][18]
- Anyone with current or past blood clots (DVT/PE) or a clotting disorder (thrombophilia)[18]
- People who had a stroke or heart attack within the last year[19]
- Undiagnosed abnormal vaginal bleeding[18]
- During pregnancy[10]
- CYP3A4 inducers reduce estrogen levels: rifampin, rifabutin, carbamazepine, oxcarbazepine, phenytoin, primidone, St. John's wort[22]
- Certain HIV/hepatitis C antivirals and cancer drugs (apalutamide, enzalutamide, mitotane) affect estrogen levels[22]
- Grapefruit products may raise estrogen levels and side effects[22]
Dosage context
Commonly-reported, not a prescription: for female hypoestrogenism, labelling describes intramuscular estradiol valerate 10–20 mg every 4 weeks; for prostate cancer it is given more often, roughly every 1–2 weeks.[16][7] Low-dose oral estradiol valerate of 2–6 mg/day has been used in some breast-cancer settings.[3] Doses must be individualised by a clinician using the lowest effective amount.[20]
Sources
- 1.DrugBank — Estradiol valerate (DB13956)
- 2.DrugBank — Estradiol (DB00783)
- 3.Wikipedia — Estradiol valerate
- 4.Synapse/PatSnap — Mechanism of estradiol valerate
- 5.DailyMed — Estradiol valerate injection
- 6.Drugs.com — Estradiol valerate injection prescribing info
- 7.MedlinePlus — Estrogen Injection
- 8.Drugs.com — Estradiol injection (MTM)
- 9.DailyMed — Estradiol valerate injection (boxed warning)
- 10.RxList — Delestrogen (estradiol valerate)
- 11.GoodRx — Delestrogen (estradiol valerate)
- 12.DailyMed — Estradiol valerate injection adverse reactions
- 13.ClinicalTrials.gov protocol — Estradiol therapy risks (trans women)
- 14.PMC — Estradiol formulations PK (oral half-life)
- 15.ClinicalTrials.gov ICF — Estradiol therapy risks
- 16.Medicine.com — Estradiol systemic dosing
- 17.DailyMed — Estradiol valerate/dienogest tablets
- 18.WebMD — Estradiol contraindications
- 19.WebMD — Estradiol stroke/heart attack contraindication
- 20.GoodRx — Delestrogen breast cancer monitoring
- 21.RxList — Estradiol endometrial sampling
- 22.Drugs.com — Estradiol injection interactions
- 23.MedlinePlus — Elagolix/Estradiol/Norethindrone surgery guidance
This information is provided for educational and harm-reduction purposes only. It is not medical advice. These substances can carry serious health risks; effects and safe use vary by individual. Consult a qualified healthcare professional before use. Legal status varies by country — it is your responsibility to know your local law. We do not encourage misuse.
Substance reviews(12)
Independent reviews of this compound from the wider market — about the substance, not our delivery. Showing the 1 with written feedback.
- ★★★★★6 months ago
package arrived but tracking shows still on the way but all good thanks guys! great service