At a glance
Effects
- Lowers estrogen: A single 25 mg daily dose suppresses circulating estradiol and estrone-sulfate by roughly 85–95% within a few days.[6][2]
- No estrogen rebound: Irreversible (suicide) inhibition means estrogen suppression persists beyond the drug's half-life and rebounds little on discontinuation.[8][9]
- Estrogen-control in AAS users: Off-label, men use it to counter aromatization from testosterone and other aromatizable steroids, reducing gynecomastia and water retention.[9][10]
- Relatively favorable lipids: Its androgen-like steroidal structure is reported to have a milder impact on cholesterol than non-steroidal AIs, though it still affects lipids.[8][9]
Steroidal aromatase inhibitor (NOT an anabolic steroid)[1][3]
~24 hours terminal (18–24 h reported)[14][9]
Oral tablet[5][9]
~42%; increased when taken with fatty food[5][6]
Hepatic via CYP3A4 and aldoketoreductases[9]
About Exemestane
Every point here is drawn from public medical and harm-reduction sources. A bracketed number after a claim — like [1]— is a reference: tap it to open the exact source it's based on (numbered list at the bottom). It is not a rating or score. Educational information, not medical advice.
Product specifics
- Est. delivery
- 3–7 business days · EU tracked
Product details as stated by the vendor (claims, not independently verified). Delivery is our standard EU estimate.
What it is
Exemestane (brand name Aromasin) is a steroidal aromatase inhibitor — a hormone therapy, NOT an anabolic steroid as the vendor spec labels it.[1][3] It is approved to treat estrogen-receptor-positive breast cancer in postmenopausal women, and in performance contexts is used off-label by men to control estrogen during anabolic steroid cycles and in post-cycle therapy.[3][11]
How it works
It is structurally related to androstenedione and acts as a "false substrate" for the aromatase enzyme: the enzyme processes it and becomes permanently, irreversibly bound and inactivated — an effect called "suicide inhibition."[5][2] By disabling aromatase, it blocks the conversion of androgens (such as testosterone) into estrogens, lowering circulating estradiol and estrone.[5][1] Because the enzyme is destroyed rather than merely blocked, the body must synthesise new aromatase to recover, so there is little estrogen "rebound" after stopping.[8]
Risks & side effects
Most important: Because exemestane sharply and durably lowers estrogen, the most important risk is estrogen deprivation: accelerated bone-mineral-density loss raising osteoporosis and fracture risk with longer use, and — if estrogen is crashed too low — joint pain, low libido, fatigue and impaired wellbeing.[5][8] Self-dosing without estradiol bloodwork can easily over-suppress estrogen, so any use should be guided by sensitive E2 testing, not symptoms alone.[10]
Common
Serious
- Accelerated bone-mineral-density loss → osteoporosis and fracture risk with long-term use[7][8]
- Crashed (over-suppressed) estrogen → joint pain, killed libido, erectile dysfunction, fatigue[10]
- Elevated liver enzymes (very common); post-marketing reports of hepatitis including cholestatic hepatitis[12]
- Possible serious cardiovascular events, higher with use beyond ~4 years and in older patients[13]
Safety & harm reduction
Dosage context
Clinically the established dose is 25 mg once daily, taken after food — this is the lowest dose giving maximal estrogen suppression in breast-cancer treatment.[6][9] In off-label male estrogen-management, community sources commonly report much lower amounts such as 12.5 mg every other day, titrated to sensitive estradiol bloodwork (a frequently cited target of ~20–40 pg/mL).[10][11] These are commonly-reported figures, NOT a prescription; over-suppressing estrogen is harmful, so any use should be guided by E2 testing.[10]
Sources
- 1.NCI – Exemestane drug page
- 2.ScienceDirect – Exemestane, a new steroidal aromatase inhibitor of clinical relevance
- 3.MedlinePlus – Exemestane drug information
- 4.Drugs.com – Aromasin/Exemestane side effects (pregnancy/contraception)
- 5.ScienceDirect Topics – Exemestane overview (mechanism, PK)
- 6.BOC Sciences – Exemestane mechanism, suppression and PK
- 7.Clinical trial protocol (NCT02871791) – Exemestane adverse events
- 8.Fit Science – Aromatase inhibitor guide for bodybuilders
- 9.Clinical trial protocol (NCT02732119) – Exemestane PK/indication
- 10.Fit Science – estradiol targets and titration (E2 20–40 pg/mL)
- 11.Medicine.com – Exemestane HCP (use, contraindications, premenopause)
- 12.Drugs.com – Exemestane hepatic effects (LFTs, hepatitis)
- 13.GoodRx – Exemestane serious heart effects and risk factors
- 14.Pfizer/RxList – Aromasin terminal half-life ~24 h
This information is provided for educational and harm-reduction purposes only. It is not medical advice. These substances can carry serious health risks; effects and safe use vary by individual. Consult a qualified healthcare professional before use. Legal status varies by country — it is your responsibility to know your local law. We do not encourage misuse.
Other options for Exemestane· 7 offers
Same compound from different labs/brands and pack sizes. Tap a row to switch brand — the price and buy button update instantly.
This compound comes in different forms (e.g. injectable vs oral vs topical). Cost per mg is only comparable within the same form.
| Brand | Form | Strength | Pack | Price | Per mg |
|---|---|---|---|---|---|
Royal Pharma | blister-pack | 20 mg/tab | 30 tab | 39,90 € | €0.067/mg |
Driada | blister-pack | 25 mg/tab | 50 tab | 64,90 € | ★€0.052/mg |
Generic | oral-liquid | 50 mg/ml | 50 ml | 94,90 € | €0.038/mg |
GenericSelected | blister-pack | 25 mg/tab | 50 tab | 104,99 € | €0.084/mg |
Generic | blister-pack | 25 mg/tab | 30 tab | 104,99 € | €0.140/mg |
Pfizer | blister-pack | 25 mg/tab | 30 tab | 109,99 € | €0.147/mg |
Generic | oral-liquid | 50 mg/ml | 100 ml | 169,99 € | ★€0.034/mg |
Substance reviews(7)
Independent reviews of this compound from the wider market — about the substance, not our delivery. Showing the 1 with written feedback.
- ★★★★★7 months ago
The product arrived eventually