• Induces ovulation (women): Restarts the hormonal cascade that matures and releases an egg; ovulation most often occurs 5–10 days after a course ^[1][2][8].
• Raises endogenous testosterone (men): Off-label, restores testicular testosterone production via increased LH/FSH while preserving fertility, unlike exogenous testosterone ^[4][9][10].
• Post-cycle / HPG-axis recovery: Used off-label after anabolic-steroid use as a SERM to help reverse suppression of the pituitary–gonadal axis and restore natural testosterone ^[9].
• Raises estradiol (men): Because zuclomiphene is estrogenic, clomiphene also raises estradiol, which can drive estrogenic side effects such as breast tenderness ^[10][11].

Est. delivery

3–7 business days · EU tracked

Product details as stated by the vendor (claims, not independently verified). Delivery is our standard EU estimate.

Clomiphene citrate is a non-steroidal selective estrogen receptor modulator (SERM), classed by MedlinePlus as an "ovulatory stimulant," that is FDA-approved to induce ovulation in women with anovulatory infertility ^[1][6]. It is also widely used off-label in men to raise endogenous testosterone and preserve fertility ^[4][9].

Clomiphene binds estrogen receptors in the hypothalamus and occupies them for longer than estrogen, interfering with receptor recycling and blunting estrogen's normal negative-feedback signal ^[3][7]. The brain "reads" estrogen as low, so it increases pulsatile GnRH, which drives the pituitary to release more FSH and LH ^[1][3]. In women this matures an ovarian follicle and triggers ovulation; in men the extra LH stimulates the testes' Leydig cells to make more testosterone while preserving sperm production ^[1][4][8]. It is a racemic mixture of two isomers — enclomiphene (anti-estrogenic, short-acting) and zuclomiphene (estrogenic, long-acting) ^[5][7].

1. 1.MedlinePlus – Clomiphene Drug Information
2. 2.CARE Hospitals – Clomiphene Citrate Uses & Side Effects
3. 3.Medicine.com (HCP) – Clomiphene Mechanism/Onset/Half-Life
4. 4.NCATS Inxight Drugs – Zuclomiphene Citrate
5. 5.DailyMed – CLOMID (clomiphene citrate) Label
6. 6.FDA Clomid Label (016131s026)
7. 7.ScienceDirect – Zuclomifene / Clomifene Citrate overview
8. 8.PMC – Clomiphene in periconception: fetal effects (PMC11197002)
9. 9.ScienceDirect – CC for male hypogonadism from AAS use (pilot study)
10. 10.PMC – CC or enclomiphene for male hypogonadism: systematic review (PMC12510335)
11. 11.ScienceDirect – Clomifene Citrate (pharmacology) overview