• Erectile function: Sustains penile blood flow by preserving cGMP, enabling erection in response to sexual stimulation for up to 36 hours after a single dose ^[1][5].
• BPH / lower urinary tract symptoms: Consistently reduces storage and voiding symptoms (IPSS score) in men with BPH, with improvement seen within 1–2 weeks in large placebo-controlled trials ^[6].
• Pulmonary vasodilation: Reduces elevated pulmonary vascular resistance in PAH at the FDA-approved dose of 40 mg daily, improving exercise capacity ^[2][1].
• Dosing flexibility: Half-life of ~17.5 hours permits both as-needed use (up to 36 h window) and once-daily low-dose use, accommodating different lifestyles ^[5][7].

Est. delivery

3–7 business days · EU tracked

Product details as stated by the vendor (claims, not independently verified). Delivery is our standard EU estimate.

Tadalafil is an oral phosphodiesterase type 5 (PDE5) inhibitor FDA-approved for the treatment of erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH) ^[1]. It is best known by the brand name Cialis and is distinguished within its class by an exceptionally long duration of action ^[2].

During sexual stimulation, nitric oxide (NO) is released from endothelial cells, which activates guanylate cyclase to produce cyclic guanosine monophosphate (cGMP) — the molecule that relaxes smooth muscle in the corpus cavernosum and allows blood to fill the erectile tissue ^[3]. PDE5 terminates this signal by breaking down cGMP ^[3]. Tadalafil competitively blocks PDE5, preventing cGMP degradation so smooth-muscle relaxation and increased blood flow are prolonged ^[1][2]. Crucially, tadalafil only amplifies an existing physiological signal: it requires endogenous nitric oxide from sexual stimulation to work and cannot produce an erection independently ^[3]. In pulmonary vasculature the same mechanism reduces pulmonary arterial pressure, explaining its PAH indication ^[2]. Tadalafil is highly selective: it is >10,000-fold more potent for PDE5 than for PDE3 (cardiac enzyme), greatly reducing cardiac side effects compared with less selective agents ^[4].

1. 1.StatPearls — Tadalafil (NIH/NCBI Bookshelf)
2. 2.Superpower.com — Tadalafil PDE5 Inhibitor Guide
3. 3.PMC — Tadalafil in ED: Clinical Evidence Overview
4. 4.FDA Label — CIALIS (tadalafil) NDA 21-368
5. 5.StatPearls — Tadalafil (NIH) — Dosing & Half-life
6. 6.ExchangeCME — PDE5 Mechanism in BPH (PDF)
7. 7.Drugs.com — Tadalafil Dosage Guide
8. 8.RxList — Cialis (Tadalafil) Full Prescribing Info
9. 9.Drugs.com — Tadalafil Side Effects
10. 10.ClinicalTrials.gov — Tadalafil Safety Summary (NCT03993353)
11. 11.SingleCare — Tadalafil Dosage, Forms & Strengths